Fruit flies are one of the most harmful pests with over 300 different hosts as it causes extensive damage to fruits and vegetables. The economic importance of this pest is something to be concerned about and efforts to control it are necessary as it is evident by the reports of almost 90% loss of yields in several fruits and vegetables. Being an insect that has a complete metamorphosis, it goes through the phases of egg, larvae, pupae and adult. Among different methods of controlling fruit flies, the bio-control approach is also one which is used widely and has been successful across several countries like Japan to control and lower down the level of fruit flies population to a more acceptable level. The bio-control approaches include bio-pesticides, entomophagous nematodes, parasitoides, predators and sterilizing male techniques whose efficacy are demonstrated by several instances in which they proved to be successful in several academic writings.